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Estrone (E1) is produced from the aromatisation of androstenedione and the reduction of E2 to E1. It has considerable estrogenic activity although it is less potent than E2.
Estriol (E3) is a metabolite of E1 and E2. It is a weaker estrogen which is capable of exerting either antagonistic or agonistic effects depending on dosage, or whether it is given alone or in conjunction with a stronger estrogen such as E2. It has been shown to be clinically effective for the treatment of menopause-related symptoms such as hot flashes, insomnia and poor memory. In addition, postmenopausal conditions of vaginal atrophy with accompanying dryness, vaginal infections and dyspareunia; and urinary tract changes resulting in recurrent UTIs, urgency, incontinence and frequent urination are helped considerably with E3.
Estradiol (E2) is about 10 times as potent as E1 and about 80 times as potent as E3 in its estrogenic effect. Except during the early follicular phase of the menstrual cycle, its serum levels are somewhat higher than that of E1 during the reproductive years of females. Thus it is the predominant estrogen during reproductive years both in terms of serum levels and estrogenic activity. During menopause E1 is the predominant circulating estrogen and during pregnancy E3 is the predominant circulating estrogen in terms of serum levels.
- Hot flushes
- Irregular menstruation
- Mood changes
- Vaginal dryness
- Bone loss
- Dry skin
- Low libido
NOTICE TO PATIENTS
NutriPATH practices in the usual practitioner-referral system for pathology laboratories. Patients are highly recommended to seek the supervision and guidance of a qualified healthcare practitioner for the interpretation of any lab results and associated information. NutriPATH can offer assistance in locating a suitable practitioner.