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Achlorhydria is the most common cause of elevated serum gastrin levels. The most common cause for achlorhydria is treatment of gastroduodenal ulcers, nonulcer dyspepsia or gastroesophageal reflux with proton pump inhibitors (eg. omeprazole). Other causes of hypo- and achlorhydria include chronic atrophic gastritis with or without pernicious anemia, gastric ulcer and gastric carcinoma.
If serum B12 levels are significantly low, a serum gastrin level above the reference range makes it more likely a patient is suffering from pernicious anemia. Gastrin levels can also be used for investigation of patients suspected of having Zollinger-Ellison syndrome.
- Pernicious anaemia
- Gastric ulcer
- Zollinger-Ellison syndrome
NOTICE TO PATIENTS
NutriPATH practices in the usual practitioner-referral system for pathology laboratories. Patients are highly recommended to seek the supervision and guidance of a qualified healthcare practitioner for the interpretation of any lab results and associated information. NutriPATH can offer assistance in locating a suitable practitioner.