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IGF-1, also known as Somatomedin C, is a polypeptide hormone similar in structure to insulin and primarily produced in the liver. It is one of the main mediators of the actions of growth hormone in promoting muscular and skeletal growth. IGF-1 is itself a powerful anabolic hormone, and it also prevents premature cell death by inhibiting apoptosis. Because of its similarity to insulin, it also weakly activates the insulin receptor and therefore has insulin-like effects when present in large quantities.
Circulating IGF-1 is almost 100% bound to IGF binding proteins (IGFBP), the most abundant of these being IGFBP-3. These binding proteins stabilize IGF-1, prolonging its half-life in the bloodstream. Blood levels of IGF-1 are low in young children, peaking during the pubertal growth spurt and then declining steadily with age.
NOTICE TO PATIENTS
NutriPATH practices in the usual practitioner-referral system for pathology laboratories. Patients are highly recommended to seek the supervision and guidance of a qualified healthcare practitioner for the interpretation of any lab results and associated information. NutriPATH can offer assistance in locating a suitable practitioner.