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IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. Production is stimulated by growth hormone (GH) and can be dysfunctional due to under nutrition, growth hormone insensitivity and lack of growth hormone receptors. Approximately 98% of IGF-1 is always bound to one of 6 binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio.
IGF-1 is a primary mediator of the effects of growth hormone (GH). Growth hormone is made in the anterior pituitary gland, released into the blood stream and then stimulates the liver to produce IGF-1. IG
F-1 then stimulates systemic body growth and has growth-promoting effects on almost every cell in the body especially skeletal muscle, cartilage, bone, liver, kidney, nerves, skin and lungs. In addition to the insulin-like effects, IGF-1 can also regulate cell growth and development especially in nerve cells as well as cellular DNA synthesis.
- Chronic fatigue
- Lack of stamina
- Sexual dysfunction
- Loss of muscle tone
NutriPATH practices in the usual practitioner-referral system for pathology laboratories. Patients are highly recommended to seek the supervision and guidance of a qualified healthcare practitioner for the interpretation of any lab results and associated information.
NutriPATH can offer assistance in locating a suitable practitioner.