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C-reactive protein (CRP) is one of the most abundant acute phase proteins in humans. Its increased production by the liver is triggered by proinflammatory cytokines as a result of infection, tissue damage, inflammation and malignant neoplasia. CRP is therefore a biomarker of systemic inflammation.
Essential fatty acids (EFAs) are known for their role in cytokine and eicosanoid (prostaglandin) production; key modulators of the immune system and inflammatory processes. Arachidonic acid (AA) and eicosapentaenoic acid (EPA) are the key EFAs modulating inflammation. AA is an omega 6 pro-inflammatory EFA whilst EPA is an omega 3 anti-inflammatory EFA. The AA: EPA ration is therefore a marker of inflammation and the balance of pro-inflammatory versus anti-inflammatory EFAs in the body. When the ratio is high it indicates increased levels of inflammation in the body and has been detected in insulin resistance, coronary artery disease and depression.
The 17-ketosteroid and 17-OH corticoid analytes are androgen and glucocorticoid urinary metabolites respectively which provide information on the balance of anabolism versus catabolism. Low levels of 17-ketosteroids represent a poor response to stress and in chronic illness indicate an unfavourable prognosis. An elevated level of 17-OH corticoid may indicate a cortisol excess, high level of stress or inflammation, hyperthyroidism or excessive hydrocortisone dosing that exceeds the capacity for metabolism.
- Autoimmune diseases
- Congestive heart failure
- Chronic inflammation – prostatitis, pancreatitis, glomerulonephritis, pelvic inflammatory disease
- Rheumatoid arthritis
- Inflammatory Bowel Disease – Crohn’s, Ulcerative colitis
NOTICE TO PATIENTS
NutriPATH practices in the usual practitioner-referral system for pathology laboratories. Patients are highly recommended to seek the supervision and guidance of a qualified healthcare practitioner for the interpretation of any lab results and associated information. NutriPATH can offer assistance in locating a suitable practitioner.