M2 Pyruvate Kinase (M2-PK) – Stool (Test Code 2012)

M2 Pyruvate Kinase (M2-PK), as measured in faeces, is a tumour marker for colorectal cancer.  Though M2-PK can be elevated in many tumour types, rather than being an organ-specific tumour marker, increased stool (faecal) levels can be used as a early detection of colorectal carcinomas.


M2 Pyruvate Kinase

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Patient Brochure

The detection of M2-PK does not depend on blood in the stool and is specifically related to changes in tumour metabolism. The M2-PK test is a non-invasive stool test that can be used for the early detection of colorectal cancers and polyps which are known to be the precursors of colorectal cancer.

Increased M2-PK values can sometimes also occur in severe inflammatory diseases which must be excluded by differential diagnosis. If elevated levels of M2PK are present, it is recommended to request more specific tumour marker tests such as (CEA) for bowel cancer, CA 19-9 for pancreatic cancer and CA 72-4 for gastric cancer. This will significantly increase the sensitivity to detect various cancers.

M2PK can be ordered as a single marker or in alliance with a CDSA panel that includes certain GIT markers.

Common Conditions:

  • Bloating, pain or nausea
  • Loose or watery stools
  • Undigested food in the stool
  • Hypochlorhydria
  • Food intolerances
  • Gastroesophageal reflux symptoms
  • Diabetes
  • Cholecystectomy
  • Osteoporosis




NutriPATH practices in the usual practitioner-referral system for pathology laboratories. Patients are highly recommended to seek the supervision and guidance of a qualified healthcare practitioner for the interpretation of any lab results and associated information. NutriPATH can offer assistance in locating a suitable practitioner.



M2 Pyruvate Kinase (M2-PK)