Oxidative Damage Markers Comprehensive Blood EDTA & Spot Urine (Test Code: 4019)

Cardiovascular disease, cancer, Alzheimer’s disease, cataracts and other degenerative diseases can occur because of oxidative damage.  Free radicals can directly modify genetic material, oxidise lipids and cell membranes and damage proteins, leading to tissue breakdown, accelerated ageing and disease.


8-Hydroxydeoxyguanosine (8-OHdG), Allantoin, Carbonyl Proteins, Malonyldialdehyde (MDA).

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Urinary levels of 8OHdG are used as a marker of DNA oxidative damage.  Elevated levels are consistent with excess free radical damage of genes.

Reactive oxygen species not only attack DNA but lipid membranes; a process known as lipid peroxidation.  Malondialdehyde (MDA) is a major by product created during this process.  Therefore MDA can be used a marker of oxidative stress of membrane oxidation and the need for fat soluble vitamins.

Uric acid is the final product of purine metabolism and can be oxidised to allantoin by reactive oxygen species.  It is the oxidative waste product of the muscle and other visceral tissue.  Therefore allantoin can be used a marker for the assessment of muscle oxidative stress.

Reactive carbonyl compounds are formed during oxidation of carbohydrates and lipid peroxidation.  These compounds are intermediates in the formation of advance glycation end products (AGEs) which can produce more free radicals and activate pro inflammatory cytokines.

Common Conditions:

  • Ageing
  • Cardiovascular disease
  • Cognitive function
  • Hypertension
  • Inflammatory conditions, e.g. Psoriasis, Rheumatoid arthritis
  • Chronic disease e.g. Diabetes




NutriPATH practices in the usual practitioner-referral system for pathology laboratories. Patients are highly recommended to seek the supervision and guidance of a qualified healthcare practitioner for the interpretation of any lab results and associated information. NutriPATH can offer assistance in locating a suitable practitioner.



8-Hydroxydeoxyguanosine (8-OHdG)
Carbonyl Proteins
Malonyldialdehyde (MDA).