myDNA Fertility Report - Male

Description

The myDNA Fertility Report – Male is a personalised and evidence-based approach to male infertility providing insights that can identify underlying genetic predispositions, specific nutrient needs, and environmental factors that may optimise health and improve fertility outcomes. This Report has been designed to analyze SNPs that influence the most significant factors affecting male fertility including sperm production, motility, morphology, DNA integrity, hormone balance, and overall reproductive health.

In Australia, male infertility remains a significant clinical concern. Current estimates indicate that approximately 5–7% of Australian men experience infertility. Among couples experiencing fertility challenges, affecting roughly one in six couples. Male factor infertility is identified as the sole or contributing cause in approximately 30–40% of cases. These figures are consistent with global trends, which have shown a progressive decline in male reproductive parameters, including sperm count and motility, over the past several decades. Such data underscore the importance of evaluating male fertility as a routine component of infertility assessments in clinical practice.

Dietary patterns for men that are high in sugar, processed red meat, refined carbohydrates, saturated fatty acids, and alternative sweeteners and low in Omega-3 fatty acids, monounsaturated fatty acids, antioxidants, fruits and vegetables have all been shown to drastically impact fertility due to elevated oxidative stress levels.

In addition, environmental exposures can impair spermatogenesis, reduce sperm concentration and motility, and increase sperm DNA damage. Exposure to pesticides, herbicides, heavy metals, phthalates, and BPA plastic is hypothesized to be a leading cause of the global decline in sperm count and concentration, poor motility, and morphology.

During natural conception or routine IVF, oxidative damage to the sperm membrane can block fertilization, preventing the damaged paternal DNA from creating an embryo. The risk is even higher in obese men with diabetes, dyslipidaemia or metabolic syndrome.

Key Genetic Markers Analysed:
This Male Fertility Report identifies 24 genes that influence the most significant factors affecting male infertility including sperm production, motility, morphology, hormone balance and overall reproductive health.

Key Nutrients Assessed:
This Male Fertility Report assesses key nutrients including Vitamin C, Vitamin E, Vitamin B12, Folate, Zinc, Vitamin D, Selenium, Omega 3 Fatty Acids, L-Carnitine, CoQ10, Arginine, Glutathione, NAC and Lycopene.

Key Environmental Factors:
Exposure to pesticides, herbicides, heavy metals, phthalates, and BPA can significantly impair spermatogenesis and induce DNA damage thus impacting fertility. This Male Fertility Report assesses the impact of these toxic influences.
This myDNA Fertility Report can greatly assist with male infertility by identifying genetic variants that impair sperm production, hormone regulation, or nutrient metabolism, enabling the Practitioner to develop targeted, personalised interventions.

Key Genes

•  • MTHFR 677
•  • SOD2
•  • CAT
•  • GPX1
•  • NRF2
•  • GST
•  • SHBG

Note: DNA Privacy Policy:
Privacy is our #1 concern. We firmly believe DNA should remain the property of your patients. Their data is stored on secure, encrypted servers, can’t be used to identify them, will never be shared with unknown third parties without consent, and has no bearing on insurance policies or premiums.