Collection Method
CI05.22.01
Kit Requirements
EDTA
Turn Around Time
21 business days Turnaround times are estimates
Description
Apolipoprotein E short for APO-E is produced primarily in the liver and brain which has two primary distinct roles:
- The transport of lipids from where they are made or absorbed to the tissues where they are stored.
- The transport of cholesterol and other lipids from the body’s organs to the liver for excretion.
The APOE gene exists in three different forms (alleles) – e2, e3, and e4 – with e3 being the most common allele, found in 60 per cent of the general population. Everyone inherits two APOE genes, one from each parent that is some combination of these three forms.
Recent studies have shown that the APO E gene test is a useful diagnostic test to help confirm a diagnosis of Type III hyperlipoproteinaemia and a diagnosis of late onset Alzheimer’s disease (AD) in a symptomatic adult.
Why get tested?
- If you have elevated cholesterol and triglyceride levels that do not respond to lifestyle changes.
- If you suspect Alzheimer’s disease
- If you have a family history of heart disease
References:
Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science. 1993;261(5123):921‐923. doi:10.1126/science.8346443
Marais AD. Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease. Pathology. 2019;51(2):165-176. doi:10.1016/j.pathol.2018.11.002
Analytes
-
APO E- (alleles)
- e2
- e3
- e4
Test Method
PCR genotyping
Notice To Patients
NutriPATH practices in the usual practitioner-referral system for pathology laboratories. Patients are highly recommended to seek the supervision and guidance of a qualified healthcare practitioner for the interpretation of any lab results and associated information. NutriPATH can offer assistance in locating a suitable practitioner.
How it works
Step 1
Order test
Your referring practitioner will place this order via their online portal.
Step 2
Collect Samples
A test kit will be dispatched to you and you can conveniently collect your sample in the comfort of your home.
Step 3
Return Samples
Return samples for analysis via the provided courier packaging.
Patient resources
Our highly skilled and qualified team have created a service where patients can easily gain access to a wide range of pathology testing options.
Practitioner resources
As a leader in the industry, practitioners are able to trust in our ability to provide them with the technology they need to adequately test their clients and patients.
