Changes in intestinal permeability are associated with many health conditions including autism, autoimmune disorders, food sensitivities and inflammatory bowel disease. This ‘leaky gut’ causes disease because the perturbed intestinal barrier allows toxic molecules to enter the bloodstream and poison the body. Intestinal permeability can be measured using the lactulose/mannitol test. Consider this test for the assessment of intestinal permeability and malabsorption.
The intestinal permeability test which assesses lactulose and mannitol recovery can be used to monitor improvements or deterioration in intestinal permeability as a result of therapy, disease or drug use. Furthermore, the intestinal permeability test has been used to monitor the compliance and effectiveness of a gluten-free diet in patients with Coeliac disease.
The test works on the principle that small molecules (i.e. mannitol) are readily absorbed by the intestinal villi, whilst larger molecules such as disaccharides (i.e. lactulose) are not. These water soluble non-metabolised sugar molecules after penetrating the intestinal tract are excreted into the urine. Under normal circumstances the ratio of lactulose to mannitol in urine is low (i.e lactulose is not absorbed), mannitol is absorbed. When the structure of the intestinal epithelium is jeopardised (‘leaky gut’ is present), the large sugar molecule can permeate the mucosa and is recovered in the urine. In this situation the level of lactulose is increased in the urine and therefore the ratio of lactulose to mannitol is high.
In addition to assessing leaky gut, this test can also help identify malabsorption. If a low level of mannitol which normally penetrates the intestinal epithelium is observed, it may indicate malabsorption of small molecules and possible atrophy of the intestinal villi.
- Lactulose (recovery %)
- Lactulose:Mannitol ratio
- Mannitol (recovery %)
- Other Health Conditions
- Food allergy and sensitivities
- Gut dysbiosis
- Inflammatory Bowel Disease – Ulcerative colitis, Crohn’s disease, Coeliac
- Irritable Bowel Syndrome
Notice To Patients
NutriPATH practices in the usual practitioner-referral system for pathology laboratories. Patients are highly recommended to seek the supervision and guidance of a qualified healthcare practitioner for the interpretation of any lab results and associated information. NutriPATH can offer assistance in locating a suitable practitioner.
How it works
Your referring practitioner will place this order via their online portal.
A test kit will be dispatched to you and you can conveniently collect your sample in the comfort of your home.
Return samples for analysis via the provided courier packaging.
Our highly skilled and qualified team have created a service where patients can easily gain access to a wide range of pathology testing options.
As a leader in the industry, practitioners are able to trust in our ability to provide them with the technology they need to adequately test their clients and patients.